| 2018 Tennessee Titans Schedule | ||||
| Week | Date | Opponent | Time (CT) | TV |
| 1 | Sept. 9 | at Miami | 12 Noon | FOX |
| 2 | Sept. 16 | vs Texans | 12 Noon | CBS |
| 3 | Sept. 23 | at Jaguars | 12 Noon | CBS |
| 4 | Sept. 30 | vs Eagles | 12 Noon | FOX |
| 5 | Oct. 7 | at Bills | 12 Noon | CBS |
| 6 | Oct. 14 | vs Ravens | 3:25 pm | CBS |
| 7 | Oct. 21 | at LA Chargers (London) | 8:30am | CBS |
| 8 | BYE | |||
| 9 | Nov. 5 | at Cowboys (MNF) | 7:15 pm | ESPN |
| 10 | Nov. 11 | vs Patriots | 12 Noon | CBS |
| 11 | Nov. 18 | at Colts | 12 Noon | CBS |
| 12 | Nov. 26 | at Texans (MNF) | 7:15 pm | ESPN |
| 13 | Dec. 2 | vs. Jets | 3:05 pm | CBS |
| 14 | Dec. 6 | vs Jaguars (TNF) | 7:20 pm | FOX/NFLN |
| 15 | Dec. 16 | at Giants | 12 Noon | CBS |
| 16 | Dec. 22 or 23 | vs Redskins | TBA | TBA |
| 17 | Dec. 30 | vs Colts | 12 Noon | CBS |